Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis
Identifieur interne : 003882 ( Main/Exploration ); précédent : 003881; suivant : 003883Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis
Auteurs : Mark J. Taylor [Royaume-Uni] ; Achim Hoerauf [Allemagne] ; Simon Townson [Royaume-Uni] ; Barton E. Slatko [États-Unis] ; Stephen A. Ward [Royaume-Uni]Source :
- Parasitology [ 0031-1820 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Antibactériens (pharmacologie), Brugia malayi (), Brugia malayi (microbiologie), Brugia malayi (physiologie), Doxycycline (pharmacologie), Découverte de médicament, Enfant, Femelle, Filaricides (pharmacologie), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Grossesse, Humains, Ivermectine (pharmacologie), Loase (parasitologie), Loase (traitement médicamenteux), Onchocerca volvulus (), Onchocerca volvulus (microbiologie), Onchocerca volvulus (physiologie), Onchocercose (parasitologie), Onchocercose (traitement médicamenteux), Symbiose (), Wolbachia (), Wolbachia (croissance et développement).
- MESH :
- croissance et développement : Wolbachia.
- microbiologie : Brugia malayi, Onchocerca volvulus.
- parasitologie : Filariose lymphatique, Loase, Onchocercose.
- pharmacologie : Antibactériens, Doxycycline, Filaricides, Ivermectine.
- physiologie : Brugia malayi, Onchocerca volvulus.
- traitement médicamenteux : Filariose lymphatique, Loase, Onchocercose.
- Animaux, Brugia malayi, Découverte de médicament, Enfant, Femelle, Grossesse, Humains, Onchocerca volvulus, Symbiose, Wolbachia.
English descriptors
- KwdEn :
- Animals, Anti-Bacterial Agents (pharmacology), Brugia malayi (drug effects), Brugia malayi (microbiology), Brugia malayi (physiology), Child, Doxycycline (pharmacology), Drug Discovery, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (parasitology), Female, Filaricides (pharmacology), Humans, Ivermectin (pharmacology), Loiasis (drug therapy), Loiasis (parasitology), Onchocerca volvulus (drug effects), Onchocerca volvulus (microbiology), Onchocerca volvulus (physiology), Onchocerciasis (drug therapy), Onchocerciasis (parasitology), Pregnancy, Symbiosis (drug effects), Wolbachia (drug effects), Wolbachia (growth & development).
- MESH :
- chemical , pharmacology : Anti-Bacterial Agents, Doxycycline, Filaricides, Ivermectin.
- drug effects : Brugia malayi, Onchocerca volvulus, Symbiosis, Wolbachia.
- drug therapy : Elephantiasis, Filarial, Loiasis, Onchocerciasis.
- growth & development : Wolbachia.
- microbiology : Brugia malayi, Onchocerca volvulus.
- parasitology : Elephantiasis, Filarial, Loiasis, Onchocerciasis.
- physiology : Brugia malayi, Onchocerca volvulus.
- Animals, Child, Drug Discovery, Female, Humans, Pregnancy.
Abstract
Anti-
Url:
DOI: 10.1017/S0031182013001108
PubMed: 23866958
PubMed Central: 3884836
Affiliations:
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Le document en format XML
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Taylor</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Liverpool School of Tropical Medicine</institution>,<addr-line>Pembroke Place, Liverpool, L3 5QA</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute for Medical Microbiology, Immunology and Parasitology</addr-line>,<institution>University Hospital Bonn</institution>,<addr-line>Sigmund-Freud-Strasse 25, 53105 Bonn</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Townson, Simon" sort="Townson, Simon" uniqKey="Townson S" first="Simon" last="Townson">Simon Townson</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Tropical Parasitic Diseases Unit</addr-line>,<institution>Northwick Park Institute for Medical Research</institution>,<addr-line>Watford Road, Harrow, Middlesex HA1 3UJ</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Slatko, Barton E" sort="Slatko, Barton E" uniqKey="Slatko B" first="Barton E." last="Slatko">Barton E. Slatko</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>New England Biolabs, Inc., 240 County Road, Ipswich, MA 01938</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ward, Stephen A" sort="Ward, Stephen A" uniqKey="Ward S" first="Stephen A." last="Ward">Stephen A. Ward</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Liverpool School of Tropical Medicine</institution>,<addr-line>Pembroke Place, Liverpool, L3 5QA</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Parasitology</title><idno type="ISSN">0031-1820</idno><idno type="eISSN">1469-8161</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Brugia malayi (drug effects)</term><term>Brugia malayi (microbiology)</term><term>Brugia malayi (physiology)</term><term>Child</term><term>Doxycycline (pharmacology)</term><term>Drug Discovery</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Filaricides (pharmacology)</term><term>Humans</term><term>Ivermectin (pharmacology)</term><term>Loiasis (drug therapy)</term><term>Loiasis (parasitology)</term><term>Onchocerca volvulus (drug effects)</term><term>Onchocerca volvulus (microbiology)</term><term>Onchocerca volvulus (physiology)</term><term>Onchocerciasis (drug therapy)</term><term>Onchocerciasis (parasitology)</term><term>Pregnancy</term><term>Symbiosis (drug effects)</term><term>Wolbachia (drug effects)</term><term>Wolbachia (growth & development)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antibactériens (pharmacologie)</term><term>Brugia malayi ()</term><term>Brugia malayi (microbiologie)</term><term>Brugia malayi (physiologie)</term><term>Doxycycline (pharmacologie)</term><term>Découverte de médicament</term><term>Enfant</term><term>Femelle</term><term>Filaricides (pharmacologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Grossesse</term><term>Humains</term><term>Ivermectine (pharmacologie)</term><term>Loase (parasitologie)</term><term>Loase (traitement médicamenteux)</term><term>Onchocerca volvulus ()</term><term>Onchocerca volvulus (microbiologie)</term><term>Onchocerca volvulus (physiologie)</term><term>Onchocercose (parasitologie)</term><term>Onchocercose (traitement médicamenteux)</term><term>Symbiose ()</term><term>Wolbachia ()</term><term>Wolbachia (croissance et développement)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Doxycycline</term><term>Filaricides</term><term>Ivermectin</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Wolbachia</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brugia malayi</term><term>Onchocerca volvulus</term><term>Symbiosis</term><term>Wolbachia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Loiasis</term><term>Onchocerciasis</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Wolbachia</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Brugia malayi</term><term>Onchocerca volvulus</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Brugia malayi</term><term>Onchocerca volvulus</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Loase</term><term>Onchocercose</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Loiasis</term><term>Onchocerciasis</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antibactériens</term><term>Doxycycline</term><term>Filaricides</term><term>Ivermectine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Brugia malayi</term><term>Onchocerca volvulus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brugia malayi</term><term>Onchocerca volvulus</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term><term>Loase</term><term>Onchocercose</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Child</term><term>Drug Discovery</term><term>Female</term><term>Humans</term><term>Pregnancy</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Brugia malayi</term><term>Découverte de médicament</term><term>Enfant</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Onchocerca volvulus</term><term>Symbiose</term><term>Wolbachia</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><p>Anti-<italic>Wolbachia</italic> therapy delivers safe macrofilaricidal activity with superior therapeutic outcomes compared to all standard anti-filarial treatments, with the added benefit of substantial improvements in clinical pathology. These outcomes can be achieved, in principle, with existing registered drugs, e.g. doxycycline, that are affordable, available to endemic communities and have well known, albeit population-limiting, safety profiles. The key barriers to using doxycycline as an mass drug administration (MDA) strategy for widespread community-based control are the logistics of a relatively lengthy course of treatment (4–6 weeks) and contraindications in children under eight years and pregnancy. Therefore, the primary goal of the anti-<italic>Wolbachia</italic> (A·WOL) consortium is to find drugs and regimens that reduce the period of treatment from weeks to days (7 days or less), and to find drugs which would be safe in excluded target populations (pregnancy and children). A secondary goal is to refine regimens of existing antibiotics suitable for a more restricted use, prior to the availability of a regimen that is compatible with MDA usage. For example, for use in the event of the emergence of drug-resistance, in individuals with high loiasis co-infection and at risk of severe adverse events (SAE) to ivermectin, or in post-MDA ‘endgame scenarios’, where test and treat strategies become more cost effective and deliverable.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Amazigo, U" uniqKey="Amazigo U">U. Amazigo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ash, L R" uniqKey="Ash L">L. R. Ash</name></author><author><name sortKey="Riley, J M" uniqKey="Riley J">J. M. Riley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bockarie, M J" uniqKey="Bockarie M">M. J. Bockarie</name></author><author><name sortKey="Deb, R" uniqKey="Deb R">R. Deb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, B K" uniqKey="Chu B">B. K. 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Harry</name></author><author><name sortKey="Dailey, H A" uniqKey="Dailey H">H. A. Dailey</name></author><author><name sortKey="Landmann, F" uniqKey="Landmann F">F. Landmann</name></author><author><name sortKey="Ford, L" uniqKey="Ford L">L. Ford</name></author><author><name sortKey="Taylor, M J" uniqKey="Taylor M">M. J. Taylor</name></author><author><name sortKey="Carlow, C K S" uniqKey="Carlow C">C. K. S. Carlow</name></author><author><name sortKey="Foster, J M" uniqKey="Foster J">J. M. Foster</name></author><author><name sortKey="Slatko, B E" uniqKey="Slatko B">B. E. Slatko</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li><li>États-Unis</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Taylor, Mark J" sort="Taylor, Mark J" uniqKey="Taylor M" first="Mark J." last="Taylor">Mark J. Taylor</name></noRegion><name sortKey="Townson, Simon" sort="Townson, Simon" uniqKey="Townson S" first="Simon" last="Townson">Simon Townson</name><name sortKey="Ward, Stephen A" sort="Ward, Stephen A" uniqKey="Ward S" first="Stephen A." last="Ward">Stephen A. Ward</name></country><country name="Allemagne"><noRegion><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Slatko, Barton E" sort="Slatko, Barton E" uniqKey="Slatko B" first="Barton E." last="Slatko">Barton E. Slatko</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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